We introduce a mixed characteristic analog of log canonical centers in characteristic \(0\) and centers of \(F\)-purity in positive characteristic, which we call centers of perfectoid purity. We show that their existence detects (the failure of) normality of the ring. We also show the existence of a special center of perfectoid purity that detects the perfectoid purity of \(R\), analogously to the splitting prime of Aberbach and Enescu, and investigate its behavior under étale morphisms.